Last updated: November 2026
Most patients see well within days of cataract surgery, so a patient who does not is worrying for everyone. Thinking by timing (day 1, the first weeks, months to years) and by layer (refraction, ocular surface, cornea, anterior chamber, IOL and capsule, vitreous, retina and optic nerve) quickly finds the cause and spots the emergencies.
Same-day red flags: increasing pain, worsening vision, hypopyon or fibrin, lid swelling and discharge (endophthalmitis); very high IOP; a wound leak or shallow chamber; a curtain or new floaters (retinal detachment).
| When | Common causes | Look for |
|---|---|---|
| Day 1 | Corneal oedema, raised IOP (retained viscoelastic), residual refractive error, wound leak, retained lens fragment, TASS, drug toxicity | Corneal clarity, IOP, chamber depth, Seidel test, AC reaction |
| Days 2–7 | Endophthalmitis (usually days 2–7), raised IOP, worsening oedema, uveitis | Pain, hypopyon, vitritis, red reflex |
| Weeks 2–8 | Cystoid macular oedema (Irvine-Gass, peaks at 4–6 weeks), dry eye, residual refraction, IOL decentration or tilt, negative dysphotopsia, retinal detachment | OCT macula, refraction, topography, dilated fundus |
| Months to years | Posterior capsule opacification, IOL opacification (calcification of some hydrophilic lenses), late IOL dislocation (pseudoexfoliation), epiretinal membrane, AMD or diabetic maculopathy, glaucoma | Retro-illumination, OCT, IOP and disc |
| Any time: pre-existing | Amblyopia, macular disease, glaucoma, optic atrophy missed before surgery | Old records, fellow eye, OCT and fields |
| Layer | Causes | Key test |
|---|---|---|
| Refraction | Residual sphere or astigmatism, refractive surprise, anisometropia | Refraction and pinhole; keratometry; see refractive surprise |
| Ocular surface | Dry eye, drop toxicity, exposure | Tear break-up time, staining |
| Cornea | Oedema (Fuchs, endothelial damage), Descemet detachment, induced astigmatism | Pachymetry, specular microscopy, AS-OCT |
| Anterior chamber | Inflammation, hyphaema, retained fragment, TASS, endophthalmitis | Slit lamp, gonioscopy for hidden fragments |
| IOL and capsule | Decentration, tilt, wrong power, toric rotation, PCO, capsular block, opacification, glistenings | Slit lamp with dilation, retro-illumination |
| Vitreous and retina | CME, vitreous haemorrhage, retinal detachment, endophthalmitis, unmasked AMD or diabetic maculopathy, ERM | Dilated fundus, OCT, B-scan if no view |
| Optic nerve | Glaucoma, ischaemic optic neuropathy after surgery | IOP, disc, fields, RAPD |
In the clinic
| Cause | Management |
|---|---|
| Residual refractive error | Glasses; contact lens; IOL exchange or piggyback, or laser vision correction after stabilisation |
| Corneal oedema | Topical steroids and hypertonic saline; usually clears in days to weeks; persistent oedema may need endothelial keratoplasty |
| Raised IOP | Topical and oral pressure-lowering drugs; burp the side port if very high on day 1 |
| CME | Topical NSAID plus steroid; sub-Tenon or intravitreal steroid if resistant; treat risk factors (diabetes, uveitis, ERM) |
| Dry eye | Preservative-free lubricants; reduce toxic drops; treat lid disease |
| PCO | Nd:YAG capsulotomy |
| IOL problems | Rotation for toric misalignment; repositioning, exchange or fixation for decentration or dislocation |
| Endophthalmitis or retinal detachment | Emergency referral to vitreoretinal service |
Pearls
Common mistakes
Related: Refractive Surprise After Cataract Surgery: Causes and Management, Positive vs Negative Dysphotopsia After Cataract Surgery, Posterior Capsule Opacification, Nd:YAG Capsulotomy and IOL Dislocation, After Cataract Surgery: Day-by-Day Care, Dos and Don’ts, Intracameral Drugs in Cataract Surgery: Moxifloxacin, Cefuroxime, Adrenaline, Lignocaine and Mydrane, With Dilution Safety.
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